BLOOD

Platelets and Clotting



BLOOD:
" INTRODUCTION
" ROLE OF BLOOD
" COMPOSITION OF BLOOD
" Plasma
" Red Blood Cells
" Blood Type
" White Blood Cells
" Platelets and Clotting
" PRODUCTION AND ELIMINATION OF BLOOD CELLS
" Red Blood Cell Diseases
" White Blood Cell Diseases
" Coagulation Diseases
" BLOOD BANKS
" Blood Transfusion
" Blood Count
" Blood donation and registry
" Blood gas analysis
" Blood sugar tests
" Blood typing and crossmatching
" Blood urea nitrogen test
" Blood-viscosity reducing drugs
Circulatory System:
" INTRODUCTION
" COMPONENTS OF THE CIRCULATORY SYSTEM
" OPERATION AND FUNCTION
" Systemic Circulation
" Pulmonary Circulation
" Additional Functions
" Blood Pressure
" DISEASES AND DISORDERS
" HEART
Vasculature System:
" Arteries
" Veins
" Capillaries
" Vasculature of the Arm
" Vasculature of the Head
" Vasculature of the Leg
" Vasculature of the Torso

Platelets and Clotting

Thrombocytes and Clotting

Thrombocytes, or platelets, are the smallest cellular component of blood. They circulate inactivated, about 250,000 per cubic mm of blood, until they come into contact with a damaged blood vessel. At this point, the platelets form a clump, adhering to each other and to the blood vessel wall. They secrete chemicals that alter a blood-borne protein, fibrinogen, so that it forms a mesh of fibers at the damage site. A clot forms when platelets and red and white blood cells become trapped in the fibers. Blood clotting begins within seconds of injury. The same process can produce unwelcome clots in undamaged blood vessels.

The smallest cells in the blood are the platelets, which are designed for a single purpose�to begin the process of coagulation, or forming a clot, whenever a blood vessel is broken. As soon as an artery or vein is injured, the platelets in the area of the injury begin to clump together and stick to the edges of the cut. They also release messengers into the blood that perform a variety of functions: constricting the blood vessels to reduce bleeding, attracting more platelets to the area to enlarge the platelet plug, and initiating the work of plasma-based clotting factors, such as fibrinogen. Through a complex mechanism involving many steps and many clotting factors, the plasma protein fibrinogen is transformed into long, sticky threads of fibrin. Together, the platelets and the fibrin create an intertwined meshwork that forms a stable clot. This self-sealing aspect of the blood is crucial to survival.

World Health Organization

Blood Clot in the Legs

Deep venous thrombosis (DVT) refers to a blood clot embedded in one of the major deep veins of the lower legs, thighs, or pelvis. A clot blocks blood circulation through these veins, which carry blood from the lower body back to the heart. The blockage can cause pain, swelling, or warmth in the affected leg.

Next: Blood Clot in the Legs

Blood Culture

A blood culture is done when a person has symptoms of a blood infection, also called bacteremia. Blood is drawn from the person one or more times and is tested in a laboratory to find and identify any microorganism present and growing in the blood. If a microorganism is found,...

Next: Blood Culture